Pituitary tumor recurrence rates are still high. The recurrence rate varies among different types of pituitary tumors, for example, the recurrence rate of lactational adenoma is about 40% at 5 years after surgery; the recurrence rate of growth hormone adenoma is about 13% after surgery. For pituitary tumor recurrence cases, regular review and follow-up should be emphasized, and regular long-term and standardized follow-up should be performed at 1 month, 3 months, 6 months, 1 year, and then annually after surgery. Because of early detection of recurrent tumor, early intervention can be taken. The intervention is mainly based on re-surgical treatment, and post-operative radiotherapy is recommended routinely. In case of third recurrence, radiotherapy is also required immediately after surgery.