The survival time of interstitial changes in both lungs cannot be generalized, for example, the survival time of idiopathic pulmonary fibrosis is shorter, about 5-10 years, while in patients with secondary interstitial changes in both lungs, the survival time mainly depends on the primary disease. Interstitial lung changes are mainly divided into primary interstitial lung changes and secondary interstitial lung changes. Primary interstitial lung changes have no clear etiology and are also known as idiopathic interstitial lung disease, which has a poor prognosis, occurring mostly after the age of 50, with a survival time of about 5-10 years. The survival of secondary interstitial lung changes depends mainly on the primary disease and whether standardized treatment is taken, and the majority of patients can survive for a long time after active standardized treatment, such as interstitial lung changes caused by connective tissue disease, the early development of the disease is slow, and the survival time of patients with active treatment is longer. Interstitial changes in both lungs are prone to co-infection, and anti-infection treatment should be considered, along with attention to nursing care, enhanced nutrition, and optional oxygen supplementation if necessary.