The course of Azithromycin for Mycoplasma infection cannot be generalized, but should be used reasonably by the doctor according to the patient’s specific condition. If the effect is still not obvious after 5 consecutive days, it is recommended to adjust the medication. Mycoplasma is a common clinical pathogenic microorganism, between the size of viruses and bacteria, children and adults are susceptible to infection, but more common in children. Because azithromycin has an antibiotic after-effect, it is still effective after stopping the drug. It is generally recommended to take it for 5 consecutive days and then rest for 2-3 days, and then decide whether it is necessary to continue the treatment with the drug according to the improvement of the condition. If the effect is very poor, the patient’s symptoms do not relieve, or even still progressive aggravation, it is recommended to follow medical advice to adjust the medication. For patients with severe mycoplasma infections, azithromycin can be infused intravenously for 1-7 days to control the disease. Once the disease is under control, it can be changed to oral medication. Azithromycin needs to be applied in sufficient quantity and according to the course of treatment to avoid drug resistance. Azithromycin can damage the liver and kidneys, so attention should be paid to monitoring liver and kidney function during use.