Abstract: Pericardial tumors are rare and are divided into two categories: primary and secondary tumors. Primary tumors are subdivided into benign tumors and malignant tumors. Primary tumors are commonly known as pericardial cysts and mesothelial cell tumors. Pericardial tumors are rare and are divided into two categories: primary and secondary tumors. Primary tumors are further divided into benign and malignant tumors. Primary tumors include pericardial cysts and mesothelial cell tumors, while secondary tumors are the direct spread or metastasis of malignant tumors of lung, mediastinum and lymphatic origin. Primary cardiac tumors From the perspective of surgical treatment, they should be removed surgically as much as possible. The blood supply of pericardial tumor comes from the aorta. Sometimes the tumor grows into the pericardial cavity and may involve the paracardium and the root of ascending aorta or main pulmonary artery, or it may be difficult to resect due to close adhesions, and only partially resectable or not resectable. Often, biopsies are removed for exploratory surgery, palliative resection or for pathological diagnosis purposes. Other treatments such as chemotherapy, -immunotherapy, radiation therapy, isotope therapy, pericardiotomy and drainage, open decompression, etc., should be based on the condition. A thorough consideration should be made. In 1958, Coolly et al. resected a 4+ cm diameter mesothelioma attached to the heart under extracorporeal circulation; Glenn et al. also resected a malignant fibrosarcoma attached to the pericardial surface of the right upper pulmonary vein about 5.5 cm. (a) Pericardial tumor resection Under general anesthesia, supine position, according to the tumor site, a median sternotomy, left anterior transcatheter intercostal incision or right anterior intercostal incision can be used (if necessary, 1~2 helper cartilages can be removed and the internal mammary artery can be cut and sutured). The pericardial tumor is well exposed, excised as thoroughly as possible, and hemostasis is proper. The defective part of the pericardium does not need to be forcibly repaired, and the pericardial incision is enlarged to prevent herniation of the heart. Subsequently, mediastinal or thoracic drainage was performed. The excised specimen is sent for pathological examination. （In advanced or inoperable cases with pericardial effusion, in order to relieve the pressure on the heart, decompensated pericardial drainage can be performed and biopsy tissue can be taken for pathological examination. (iii) Radiotherapy According to the pathological diagnosis of pericardial tumor, for cases sensitive to radiation, deep X-ray, cobalt 60 or linear gas pedal radiotherapy will be used. It can relieve the symptoms. The effect is better with epithelial cells and lymphocytes. (iv) Chemotherapy The corresponding chemotherapy drugs are used according to the cell type, and the synchronous intermittent chemotherapy program is implemented. The commonly used drugs are epi-amycin, vincristine, cisplatin, carbomer, self-lipomycin, mitomycin, wyman, vincristine, isocyclic lingamide, cyclic lingamide, etc. Attention should be paid to the inhibition of the hematopoietic system by chemotherapy drugs; chemotherapy should be given under supportive therapy; and with immunotherapy (interferon, Ankang capsule, etc.). In short, comprehensive treatment is needed for good effect. Secondly, secondary pericardial tumor symptomatic treatment, repeated pericardial puncture and aspiration of fluid is an effective way to reduce pericardial pressure blockage. If we can use immune agents such as interferon (made by Schering-Plough Pharmaceutical Co., Ltd., USA) 3 million units, subcutaneous injection, 2~3 times a week, long-term use, can enhance immunity, inhibit the development of tumor disease, can be expected to extend the remission period, improve the survivability and quality of life.