Mastoproliferative disease is a common and prevalent disease in adult women. Mastoproliferative disease is a non-inflammatory and non-tumor breast disease, which is a structural disorder caused by incomplete replenishment of breast tissue after physiological hyperplasia occurs under estrogen stimulation. Therefore, some people call it “poor breast structure”. The onset of mastopathy is closely related to endocrine disorders, although the cause is not well understood, but one thing is certain, the disease is closely related to the endocrine imbalance of the ovaries. With the changes in ovarian function during the menstrual cycle, the estrogen and progesterone levels in the body also change periodically, and the structure of breast tissue also undergoes periodic changes of physiological hyperplasia and rejuvenation. If the estrogen level is too high or the progesterone level is too low, or if there is a lack of coordination between the two, it can lead to structural disorders due to incomplete mammary gland regeneration, i.e. mastopathy. Pain is the most common symptom. The most common manifestation of the disease is breast pain, which is mostly cyclical premenstrual swelling or pins-and-needles pain that can radiate to the armpits and can reduce or subside on its own after the menstrual cycle, or in some patients the pain does not change with the menstrual cycle. Most patients feel that they have a lump. In fact, mastocytosis often manifests as thickening of glandular tissue in multiple areas of the breast in the form of masses, strips or granules, and is not a lump. However, a few people with severe disease can find lumps in their breasts that are not well-defined. There is no specific treatment for this disease, and psychotherapy should be the mainstay, supplemented by medication. It is characterized by a chronic course and recurrent attacks. For some patients, if the symptoms are not serious, no medication is needed, and some of them may heal on their own; avoid fear, tension or depression, maintain a good mental state, a regular lifestyle and appropriate physical exercise is conducive to the improvement of the disease or the relief of symptoms; dietary regimen is also important in life, pay attention to a low-fat, fiber-rich, vitamin-rich diet. Those with severe symptoms can be treated with Chinese herbal medicine; severe cases can also use endocrine drugs such as triamcinolone acetonide, but these drugs have certain interference with human hormone metabolism and need to be taken under the guidance of a doctor. Most patients do not require surgical treatment, and surgery is used only if a limited and palpable mass is formed or if malignancy cannot be ruled out. With the exception of ductal epithelial atypical hyperplasia and severe papillomatosis, there is so far insufficient evidence to prove a definite relationship between mastoproliferative disease and breast cancer. It is generally believed that mastoproliferative disease is only one of the multiple risk factors for breast cancer. Mastocytosis usually does not turn into breast cancer, but it is worth noting that the lumps manifested in the early stages of breast cancer are small and not easy to find, and may be mixed with mastocytosis, sometimes not easy to identify even by doctors. Therefore, patients are reminded to visit the hospital regularly for review to prevent any missed diagnosis of breast cancer.