Epigastric pain with nausea and vomiting is mainly caused by the following diseases: 1. Pancreatic diseases, such as binge drinking, gallbladder tuberculosis, gallbladder stones, hyperlipidemia, can easily cause acute pancreatitis with epigastric pain, nausea, vomiting, fever, elevated blood count, etc., and pancreatic lesions can be seen on upper abdominal enhancement CT; 4. High intestinal obstruction and duodenal congestion.