Many patients who come to our foot and ankle clinic describe their symptoms as inexplicable sharp pain at the base of the big toe at night, and a slight movement of the toe or even a slight breeze will cause a sharp pain. This is not a specific disease, but has been described in foreign medical literature as “the devil bit my big toe”, and later named “gout”. Gout is a disorder of the metabolism of a substance called purine in the body, which increases the synthesis or decreases the excretion of uric acid, resulting in hyperuricemia. When the blood uric acid concentration is too high, uric acid is deposited in the form of sodium salts in joints, soft tissues, cartilage and kidneys, causing a foreign body inflammatory reaction in the tissues. Gout can be clinically divided into four stages: the first stage is the period of hyperuricemia, in addition to elevated blood uric acid, the patient does not appear the clinical symptoms of gout; the second stage is the early stage of gout, blood uric acid continues to increase, resulting in a sudden attack of acute gouty arthritis, most people are woken up in their sleep like a knife cut pain, the first site is often the big toe, the joint is red, swollen, burning and swollen, can not cover If the slightest wind blows or touches the toe, the pain will immediately be as severe as if the toe is moving, but it will disappear automatically within a few days or weeks, and this phenomenon of “coming and going like the wind” is called “self-limiting”. The third stage is the middle stage of gout, from the initial onset of a toe joint, gouty arthritis repeated acute attacks, after several acute attacks, gradually spread to the joints of the fingers, toes, wrists, ankles, knees and other joints throughout the body, and then the surrounding soft tissues and bones. At this time, the kidney function is normal or shows a mild decline; the fourth stage is the late stage of gout, the patient’s joint deformity and dysfunction are increasingly serious, the gouty stone increases, the volume increases In the fourth stage of gout, the patient’s joint deformity and dysfunction become more and more serious, and the gout stones increase in size, easily break down and flow out white urate crystals. Uric acid is continuously deposited into the kidney, forming kidney stones, etc. Clinical swelling, oliguria, proteinuria, increased nocturia, hypertension, anemia, etc. indicate that kidney function is damaged and kidney function is significantly reduced. If the disease develops further, kidney failure that is not easily reversible can be life-threatening. The diagnostic criteria for gout are as follows: (6 of the 12 indicators are met) 1. more than 1 acute arthritic attack. 2. Inflammatory manifestations peaking within 1 day. 3.A single episode of arthritis. 4.Redness of the joint is observed. 5, Pain or swelling of the first metatarsophalangeal joint. 6.Unilateral attack involving the first metatarsophalangeal joint. 7.Unilateral attack involving the tarsal joint. 8.Suspected gout stone. 9.Hyperuricemia. 10, Intra-articular asymmetric enlargement on X-ray. 11.Subcortical cysts without bone erosion. 12.Negative microbiological culture of joint fluid during joint inflammation attack. Treatment of gout: 1.Low purine diet. 2. Drink alkaline water. 3.Recommended drugs in the acute stage. (1) Diclofenac sodium extended-release tablets (Fotarine) 75mg orally 1/day. (2) Loxoprofen Sodium Tablets (Loxone) 60mg orally 1/day. (Both of the above drugs are prescription drugs, please purchase and take them under the guidance of a specialist practitioner). 4.Recommended drugs for intermittent or chronic period. Benzbromarone 25mg-100mg once a day.