1, siblings at the same time with precocious heart disease, parents and children at the same time with precocious heart disease is quite common, and the nature of the disease is very similar. If the first child born to a mother with precocious heart disease, the possibility of the second child suffering from the disease is about 2%; if two consecutive children with precocious heart disease, the number of children born with precocious heart disease may increase to 10%. If the mother suffers from precocious heart disease, the risk of the second generation suffering from precocious disease is 10%. 2, pregnant women with untreated and uncontrolled diabetes mellitus, the risk of congenital heart disease in the fetus is 2%, if the disease is controlled and stable in early pregnancy, the risk decreases. 3, pregnant women exposed to teratogenic drugs such as lithium, sodium phenytoin or steroids in early pregnancy can lead to a 2% risk of congenital heart disease in the fetus. 4, early pregnancy by radioactive substances such as X-rays, isotopes and other excessive exposure can cause fetal heart development malformations. 5, women in the first 3 months of pregnancy, especially the 3 weeks to 8 weeks of pregnancy, if infected with viruses, the fetus is prone to cardiovascular malformations. Among them, rubella virus is the main culprit of fetal precocious heart disease. In addition, influenza, mumps, coxsackie virus, herpes virus, etc. are also often the “perpetrators” of pediatric precocious heart disease. 6, pro-marriage on the offspring of the genetic effect has been confirmed by a large number of investigation data, is an important factor affecting the offspring of eugenics.