A thigh lipoma is a benign soft tissue tumor that grows in the subcutaneous fat of the thigh and may be observed or surgically removed. It is recommended to follow your physician’s instructions. Lipomas of the thigh are composed mainly of fat cells and usually appear as single or multiple subcutaneous, limited masses that are slow-growing and do not cause discomfort such as tenderness. Its etiology is not entirely clear, and may be related to heredity, chronic inflammation and abnormal fat metabolism. Thigh lipoma generally does not cause discomfort, but a few tumors are too large may have pressure symptoms. Lipoma is generally less harmful and can be observed and dynamically reviewed. Part of the larger tumors, faster growth rate, affecting aesthetics or producing compression symptoms of lipoma can be surgically removed. After surgery, you need to change the medicine regularly, remove the stitches, and take amoxicillin, cefaclor and other antibiotics to prevent infection.