Currently epilepsy surgery is the last option for patients with drug-refractory epilepsy. The first common surgery is epileptic focal resection, which requires identifying the site of the epileptogenic foci and taking the epileptogenic foci by craniotomy to achieve the treatment of epilepsy. Therefore, some patients with epilepsy who are not taking good medication, the site of the epileptogenic focus cannot be determined, or there are multiple epileptogenic foci, or the epileptogenic foci are located in important functional areas, cannot undergo focal resection. However, vagus nerve stimulation is an option. Vagus nerve electrical stimulation, the second procedure we will talk about, does not require precise localization of the epileptic foci, does not require craniotomy, and suppresses the excitability of cortical neurons by stimulating the vagus nerve on one side of the neck to achieve a reduction in the number of seizures and even complete control of epilepsy in some patients. Vagus nerve electrical stimulation, a non-destructive surgery, has no damage to brain tissue and function, has few side effects, can improve patients’ quality of life and memory, especially for pediatric patients, can reduce the impact of recurrent seizures on children’s intelligence, and reduce the side effects of long-term medication. Patients who meet these four types of requirements can be considered for vagus nerve stimulation: 1, after regular antiepileptic drug treatment, still can not effectively control epileptic seizures 2, multifocal or diffuse epileptic lesions, or lesions can not be clearly localized 3, can not tolerate craniotomy, or the results after craniotomy are not good 4, can not tolerate the side effects of antiepileptic drugs; patients who meet these four types of requirements can be suspended 1. Patients with a clear diagnosis of focal epilepsy, but without adequate and reasonable course of drug therapy, and who are still considered to have good results after adjustment of drug therapy from the existing treatment plan, can be temporarily treated with drugs, to be observed, and then considered for surgery if the results are still poor; 2. Patients with serious physical diseases, such as liver insufficiency with severe bleeding and clotting Patients with serious physical diseases, such as liver insufficiency with severe bleeding tendency, need to recover well before considering surgical treatment; 3, patients themselves and their families overreact to the risks of surgery, can not bear the possible risks of surgery, need to wait for the full understanding of the family before considering surgery; 4, there are intellectual defects, mental disorders symptoms patients are not suitable for surgery.