1, anti-estrogen drugs (such as: Tamoxifen) side effects: recent nausea and hot flashes, transient thrombocytopenia; long-term thrombosis, endometrial cancer, retinal degeneration, etc.; treatment: pay attention to the condition of the endometrium during taking the drug, early detection and timely treatment; if blurred vision, mosquitoes should stop the drug. 2, aromatase inhibitors (such as: letrozole, anastrozole, etc.) side effects: fatigue, headache, hot flashes, diarrhea, nausea, rash, etc., occasionally leukocyte or thrombocytopenia and permanent hyperalgesia, thrombosis; third-generation aromatase inhibitors can lead to increased incidence of osteoporosis and fractures; treatment: bone density should be monitored during the use of drugs; application of zolay phosphate can prevent bone loss, Bone loss and osteoporosis can be prevented and the incidence of fracture can be reduced. 3.Progestational drug side effects: obesity, fluid retention, hyperglycemia, hypertension, liver function damage. 4. The side effects of luteinizing hormone releasing hormone analogues (e.g. Norelide and Inhibiton): dizziness, headache, excessive sweating, flushing, male breast development, hirsutism, rash, decreased libido, edema, etc.; 5. The side effects of androgens are mainly masculine symptoms, which are manifested as seizures, increased secretion of sebaceous glands, hirsutism, hair loss, thickening of voice, etc. after 2-3 months of medication, and the symptoms can often disappear on their own after stopping medication.