Running cannot cure impotence and premature ejaculation, but there may be potential benefits of running that can help improve symptoms. Impotence, medically known as erectile dysfunction (ED), is primarily the inability of a man to maintain a sustained erection of the penis for a satisfactory sex life. Premature ejaculation (PE) refers to a persistent or recurrent pattern of ejaculation that occurs before the individual’s will within 1 minute of sexual activity with a partner in more than 1/2 of sexual encounters. 1. General treatment: It is crucial to emphasize the etiology (e.g., endocrine, psychiatric/psychological disorders, vascular diseases, etc.) and treat the primary disease. Lifestyle changes are also effective, such as scientific diet, smoking cessation, moderate exercise, and appropriate sexual frequency. 2. Psychological-behavioral treatment: Consultation in psychiatry or psychiatry, and related treatments include squeezing and stopping. 3. Drug therapy: ED is mainly sildenafil, tadalafil and other drugs, PE is mainly dapoxetine. 4. Surgery: People with ED who cannot be relieved by medication can be treated by surgery (implantation of prosthesis), and there is no effective surgery for PE. In summary, after the diagnosis of impotence or premature ejaculation should be as soon as possible to seek medical attention, under the guidance of the physician to clarify the cause of the disease, and then comply with the doctor’s instructions for treatment to improve the quality of life.