Penile vasculitis may be related to genetics, infection, medication and other causes, and formal examination is required to determine the cause. 1. Heredity: Genetic variations of HLA in the human body cause some vasculitis to have a significant genetic predisposition, and their family members have an elevated risk of developing vasculitis. 2. Infection: Infection with pathogens such as immunodeficiency virus may lead to penile vasculitis. 3. Drugs: The use of drugs such as sulfonamides and penicillin can lead to arterial vasculopathy, which may lead to penile vasculitis. In summary, it is recommended that patients with penile vasculitis go to a regular hospital in time to clarify the cause of the disease and standardize the treatment under the guidance of the doctor, so as not to delay the disease to bring adverse effects on the body.