Specialized treatment means: (a) high-intensity focused ultrasound: also known as HIFU or focused ultrasound knife. Due to the short wavelength of ultrasound, it is easy to focus, and has the penetrating property, thus after focusing ultrasound, it can get high energy density at the focal point, so that the tissues at the focal point will be warmed up rapidly, similar to the sunlight after focusing by the convex lens, which can produce high temperature at the focal point, and ignite the paper or matches. Focused ultrasonic knife is to focus ultrasonic waves on the tumor in the body, and under the supervision of ultrasound and the full control of computer, it can completely kill the tumor tissues point by point and layer by layer along the edge of the tumor (conformal therapy), and it takes several hours for a large number of apoptosis to occur when the tumor cells are at 42-43℃, and it takes 1 second for irreversible damage to occur when they are at 56℃, and it only takes 1/4 second for coagulative necrosis to occur when they are at 65-70℃. . Normal tissues in the upper layers of the tumor and tumor periphery are unaffected because they are not in focus. This kind of non-invasive but precise and efficient feature is unique among many other tumor treatment methods at present. Foreign experts have called it “the future of tumor surgery” and “green tumor treatment in the 21st century”. Focused ultrasonic knife treatment process is bloodless, no severe pain, no anesthesia, no incision, no toxic side effects of conventional treatment. It is suitable for uterine fibroids and middle and advanced malignant tumors in the abdominal and pelvic cavity, such as pancreatic cancer, posterior peritoneal tumors and metastatic pelvic and abdominal tumors, ovarian cancer, part of liver cancer, kidney cancer, adrenal gland tumors, gastric cancer, prostate cancer, and bladder cancer. The Focused Ultrasonic Knife Center of the hospital has completed 10,000 cases of HIFU treatment for various middle and late-stage malignant tumors over the past 7 years, which is a leading number in the industry and has accumulated a lot of clinical experience. Among them, 3900 cases of middle and advanced pancreatic cancer have been completed, and some patients with advanced pancreatic cancer whose survival period is expected to be within 3 months have survived for 5-6 years after receiving HIFU treatment, and some patients with inoperable low-differentiated carcinoma of the stomach have had their tumors disappeared after HIFU treatment (as confirmed by gastroscopy in many hospitals), and most of the patients with advanced tumors have prolonged their survival period and significantly improved the quality of life after HIFU treatment. The quality of life is obviously improved. (II) Iodine 125 sealed seed source intra-tumor implantation: also known as radioactive particles or in vivo Gamma Knife: the radioactive source (particles, like the size of the side foot of a staple) will be implanted into the tumor under the guidance of CT or B ultrasound, as if a miniature radiotherapy machine is implanted into the tumor to radiate low-energy gamma rays for a long period of time (with a half-life of 2 months, and it is generally believed that the effective radiation can be up to 6~8 months) to kill the tumor tissue. Since most of the radiation dose of the particles is concentrated within 1.7cm around the particles, the damage to the peripheral tissues is very small, thus radioactive particle therapy avoids the penetrating damage to normal tissues caused by external radiation therapy, and it may still be effective for tumors that have failed external radiation therapy. It is applicable to liver cancer (primary or metastatic), lung cancer, kidney cancer, other pelvic and abdominal cavity occupations, tumors on the body surface, tumors with cervical and axillary lymph node metastasis, breast cancer, rectal cancer, vaginal and cervical tumors, and so on. The Focused Ultrasonic Knife Center of the hospital has completed 1,000 cases of radioactive particle therapy for various middle and late malignant tumors in the past 5 years, the number of which is leading in Shanghai, of which 70% are liver tumors, and the puncture accuracy rate reaches 100%, without serious complications. Theoretically, all tumors will be inhibited after radioactive particle therapy. In our clinical practice, we found that 80% of the tumors are inhibited after radioactive particle implantation, which is manifested as no obvious growth in tumor volume in a longer period of time, and 50% of the tumors are reduced in volume, and a small number of tumors with a diameter of less than 3cm disappeared from the imaging after radioactive particle therapy. (C) Radiofrequency diathermy: n overview: divided into extracorporeal and intracavitary thermotherapy, non-invasive, almost applicable to all solid tumors except head and face. Since tumor tissues are not heat-resistant, if chemotherapy or radiotherapy is supplemented with heat therapy, it can greatly improve the cancer-killing effect of radiotherapy and chemotherapy and increase the efficiency of radiotherapy and chemotherapy. Principle: Tumor is afraid of heat. In the first 150 years, there are a large number of reports of spontaneous regression of histologically confirmed malignant tumors, and most of the patients have high fever due to malaria or typhoid fever or dengue fever. Modern medical research has found that due to various intrinsic reasons, tumor cells cannot tolerate high temperatures of 41 to 42.5℃, while normal cells can tolerate high temperatures below 45℃ for a long time. As a result, the high temperature of 42.5℃ can selectively kill tumor cells, while normal cells are not affected, thus giving birth to tumor hyperthermia, i.e., the use of physical methods to heat the tissue to the lethal temperature (42.5℃～43.5℃) for a period of time to achieve the purpose of destroying the tumor cells without damaging the normal tissues, and radiofrequency hyperthermia is a commonly used means of treatment. Radiofrequency diathermy is one of the commonly used means. Characteristics of radiofrequency hyperthermia: ①high thermal efficiency; ②easy to control the dosage, strong safety; ③strong penetration into tissues (up to 17cm deep); ④non-invasive treatment, no pain and other discomforts. Combination of heat therapy and chemotherapy, i.e., thermal chemotherapy, can increase the concentration of drugs in the tumor and enhance the anti-tumor effect; at the same time, it can reduce the toxic effect of chemotherapeutic drugs on the unheated normal tissues, and also help to prevent and delay the emergence of drug resistance. A large number of researches show that thermotherapy plus chemotherapy can increase the cancer-killing effect of some chemotherapeutic drugs by 10 to 100 times. The combination of thermotherapy and radiotherapy, i.e. thermal radiotherapy, can increase the cancer-killing effect by 5-8 times. (1) The survival rate of hamster ovarian cancer cells is 25.8% after irradiation by 400GY radiation; the survival rate is 17.7% after heating at 43℃ for 1 hour; the survival rate is 0.15% after combined treatment of thermotherapy and radiotherapy; (2) Heating can make the tumor cells in each cell cycle sensitive to radiation (e.g., the S-phase cells, which are insensitive to radiation, are sensitive to heating), and it can make the cells in M-phase, S-phase and G2-phase stagnant time, and make the cells in M-phase, S-phase and G2-phase stagnant time sensitive to radiotherapy. (2) Heating can make tumor cells in each cell cycle sensitive to radiation (e.g. S-phase cells, which are not sensitive to radiation, are sensitive to heating), and can prolong the stagnation time of M-phase, S-phase and G2-phase of cells to create conditions for radiotherapy; (3) Heating can increase various types of DNA damage and inhibit the repair of radiation-induced sublethal injuries; (4) Lack of oxygenated cells account for more than 25% of the tumor tissues. Simple radiofrequency hyperthermia Although simple radiofrequency hyperthermia sometimes has clear efficacy, especially for those patients with advanced tumors who are frail and cannot tolerate radiotherapy or recurrence after chemotherapy and radiotherapy, hyperthermia may be the only feasible local treatment method. However, for most patients, we still advocate the comprehensive treatment of tumors. Thermal therapy combined with radiotherapy or chemotherapy for malignant tumors can often produce unexpected results, resistance to radiotherapy, chemotherapy-resistant malignant tumors, combined with thermal therapy can also obtain significant therapeutic effects. Warm treatment (42.5℃～43.5℃) is not a radical means, it should be combined with systemic chemotherapy, radiotherapy, immunotherapy or traditional Chinese medicine, which can improve the efficacy of several times or even dozens of times, and the dose of the drug is only 1/3 or 1/2 of the commonly used amount, therefore, the drug’s toxicity and side-effects are reduced greatly and the therapeutic effect is improved significantly, which obviously improves the patient’s quality of life, and brings new hope to the cancer patients. Cancer patients have brought new hope. (iv) Thermal perfusion therapy for malignant pleural and abdominal fluid: Intra-thoracic and intra-abdominal dissemination of tumors, especially pleural or peritoneal implantation, mostly produces carcinomatous (malignant) pleural and abdominal fluid, and conventional treatment is extremely ineffective, and simple systemic chemotherapy cannot make the abdominal or thoracic lesion site reach a higher concentration of drugs. Intracavitary infusion chemotherapy can make the anti-cancer drugs gather in the abdominal cavity or thoracic cavity, which is equivalent to the tumor lesions being immersed in the solution of anti-cancer drugs, and the effect time is long (the absorption of the drugs in the body cavity is much slower than that of intravenous drugs). At this time, if it can be combined with extracorporeal hyperthermia treatment, and the solution of the anti-cancer drugs in the body cavity can be heated up to 42 ℃, then it can increase the absorption of the anti-cancer drugs by the tumor cells, and enhance the sensitivity of the tumor cells to the chemotherapy drugs, thus improving the killing effect of the latter. and thus increase the tumor-killing effect of the latter. In addition to conventional chemotherapeutic drugs, the drugs used in perfusion therapy can also be selected from certain cytokines, traditional Chinese medicines, immune agents or biological agents, tumorolytic viruses and so on. Indications of our center’s comprehensive treatment: liver cancer (primary or metastatic), pancreatic cancer, retroperitoneal tumor (primary or metastatic), gastric cancer (advanced stage, with large and fixed tumor size, which can be shown by ultrasonic examination), breast cancer, lung cancer (non-diffuse), renal cancer, adrenal tumor, uterine fibroids, ovarian cancer, prostate cancer, bladder cancer, cervical cancer, rectal cancer, superficial primary or metastatic tumors, bone tumors of specific areas, and tumors of specific areas not mentioned above. Bone tumors in specific areas, tumors not mentioned above with a diameter of 3cm or more in the abdominal cavity and with a satisfactory puncture path or acoustic channel, and carcinomatous pleural and abdominal fluid. Minimally invasive treatment is a part of comprehensive tumor treatment, which is mainly used for patients with tumors that are not suitable for radical surgical treatment, broken down as follows: 1. Tumors that are large in scope, invade important organs, and cannot be removed by surgery; 2. Patients who are frail, elderly, and have many comorbidities, and cannot tolerate surgery; 3. Tumors that have recurred or metastasized to many places after surgery, and the removal of a single lesion is no longer meaningful to the patient; 4. Tumors that are undergoing chemotherapy or radiation and need to be treated with adjuvant therapy; 5. Radiotherapy, need to cooperate with adjuvant therapy to improve the efficacy; 5. Pursuing quality of life, having concerns about radical or disfiguring surgery and refusing surgery.