The most complex form of congenital heart disease is complete transposition of the great arteries, which means that the heart and blood vessel connections are intertwined, for example, the left ventricle itself should be connected to the ascending aorta, but now the left ventricle is connected to the pulmonary artery and the right ventricle is connected to the ascending aorta, causing a displacement of the heart, resulting in hemodynamic abnormalities that seriously endanger the patient’s health. If left untreated, patients usually die within a year. In terms of treatment, it is necessary to perform either phase I or phase II treatment, depending on the complexity. If radical surgery cannot be completed in phase I, the patient’s life expectancy can only be prolonged by staged treatment in phase II or even more phases. After the surgery, medications such as cardiac strengthening and diuretics are also required to maximize the recovery of the patient’s heart function.