Most of the hypoglycemic drugs do not directly damage the liver and kidney function, but some hypoglycemic drugs have to be metabolized by the liver and excreted by the kidneys. If the patient’s liver and kidney function are not good, the excretion of the drug will be impaired, and the prototype and metabolites of the drug will slowly accumulate in the body and increase the burden on the liver and kidney, thus affecting the liver and kidney function, and should not be used at this time. When a diabetic patient first consults a doctor, the doctor will often carry out a systematic examination of the patient’s liver and kidney function, choose the appropriate medication according to the specific situation of each patient, and recommend the patient to carry out regular liver and kidney function examination. If the patient’s liver and kidney functions are normal, and the fasting and postprandial blood glucose control is satisfactory after using the drug, it can be used with complete confidence. It is recommended that diabetic patients choose a glucose-lowering program under the guidance of a professional physician.