Diabetes mellitus three plus sign refers to the urine sugar + + +, is more serious, at this time may need to cooperate with the doctor to follow the doctor’s instructions to use drugs for treatment. Diabetes mellitus is an endocrine disorder caused by absolute or relative insufficiency of insulin secretion and/or impaired utilization, with abnormally high blood glucose levels as its main clinical feature. Three plus signs of diabetes indicate that the patient’s blood glucose level is relatively high, and it is necessary to test the blood glucose to know the specific blood glucose value, and follow the doctor’s instructions to use metformin, gliclazide tablets, glimepiride tablets and other drugs for treatment to avoid acute complications of diabetes mellitus, such as diabetic ketoacidosis, hyperosmolar hyperglycemia syndrome and so on. It is important to monitor the blood glucose level regularly to clarify the development of diabetes and adjust the medication as prescribed by the doctor to avoid worsening of symptoms.