When white spots appear on the hands, the first thing to consider is whether long-term exposure to chemicals, such as rubber gloves, plastics and other chemicals, long-term stimulation may lead to localized skin white spots. If the skin on the hand has been traumatized, sunburned or inflamed, local hypopigmentation will also appear after healing. In addition, the following common clinical diseases can also be manifested as white spots on the hands. 1, senile white spots: is a kind of ageing, skin aging, melanocyte reduction caused by the round white spots, mostly seen in the middle-aged and elderly. It is a round white spot of rice grain to green bean size, and there may be a slight depression; 2. Vitiligo: it is a common acquired pigment loss skin mucous membrane disease. The cause is still unclear, considering that it may be related to genetics, neuropsychiatric, immune and endocrine metabolism. It can occur at any age and in any part of the body, manifesting as pigment loss white spots of varying color and shape; 3. Anemic nevus: a light-colored spot caused by a defect in the development of limited skin vascular tissue. It appears after birth or during childhood and does not recede for life. It can occur in any part of the body and appears as round or oval light-colored spots with clear boundaries and irregular edges; 4. Early local skin may show a piece or several light-colored spots, 1cm to several centimeters in diameter, local sensory loss or disappearance may occur, closed sweating.