Drug-resistant tuberculosis for patients who are generally first treated for tuberculosis, if the effect is not very good after a period of treatment, or patients with sputum-positive tuberculosis who are repeatedly positive in the process, it is highly important to consider whether the patient is drug-resistant. There are several types of drug resistance detection methods: 1. bacteriological testing, it is recommended that patients should come over every month to keep sputum for Mycobacterium fastidious culture, and if the culture is positive, bacterial typing and drug sensitivity testing can be done, but the cycle is longer, it takes 35-45 days to come out, and the results of sputum drug sensitivity can be tested for first-line drugs and second-line drugs; 2. molecular biology testing. If the culture of Mycobacterium sputum is positive, drug resistance gene chip test can be done, mainly for the discovery of isoniazid and rifampicin resistance gene, the cycle is about 7 days to come out; 3, Xpert test, the test is a fluorescent PCR quantitative DNA test for tuberculosis, which can find out whether there is resistance to rifampicin within 2 hours. The Xpert test, which is a fluorescent PCR quantitative DNA test for tuberculosis, can find out whether there is resistance to rifampicin within 2 hours, which can shorten the time to diagnose drug-resistant tuberculosis to a certain extent and enable earlier treatment of tuberculosis; 4. The linear probe test can detect first-line drugs, such as isoniazid, rifampicin, ethambutol and pyrazinamide.