The prevention of coronary heart disease is divided into two levels 1, primary prevention, refers to the non-drug preventive measures taken before the occurrence of coronary heart disease. Such as smoking cessation, reasonable diet, appropriate exercise, adjusting the mental and psychological state and other means. 2.Secondary prevention refers to the drug treatment for coronary heart disease on the basis of primary prevention, aiming to reduce the incidence of angina pectoris and myocardial infarction and death rate. 1.Anti-platelet drugs: Aspirin is the most widely used anti-platelet drug, which is the first-line drug for the prevention of coronary heart disease. It mainly plays its anti-platelet role by blocking the synthesis of platelet agonist thromboxane A2, and its long-term use can effectively reduce the mortality rate and the incidence of myocardial infarction in patients with coronary heart disease. 2, lipid-lowering drugs: many studies have confirmed that the use of simvastatin or pravastatin to reduce serum total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) levels can not only significantly reduce the incidence of coronary heart disease events by 30-40%, but also reduce the total mortality rate by 22-30%, and reduce the incidence of interventions, bypass surgery and strokes. The principle of using lipid-lowering drugs is to use statins for high cholesterol and betablockers for high serum triglycerides. In addition to removing serum cholesterol and LDL-cholesterol, statins can also reduce LDL-C in lipid plaques, restore vascular endothelial cell function, reduce inflammatory response, and improve plaque stability. 3, angiotensin-converting enzyme inhibitor (ACEI): ACEI and aspirin and ß-receptor blocker combined application has a superimposed effect, coronary heart disease patients are required to use. This drug should be taken for life in high-risk patients, the elderly, those with anterior wall infarction, those with a history of infarction, and those with reduced left ventricular function. 4, receptor blockers: the application of ß-receptor blockers after myocardial infarction can reduce the rate of disability and mortality. 5, antiarrhythmic drugs: several studies in Europe and North America have confirmed that amiodarone can reduce arrhythmic death and cardiac arrest in patients with ventricular arrhythmias with or without left ventricular dysfunction after myocardial infarction. Low dose maintenance is advisable during treatment to reduce the occurrence of adverse effects. 6.ABCDE system: Combining the above 5 points and primary prevention is the ABCDE system of coronary heart disease prevention. A: aspirin, angiotensin-converting enzyme inhibitor; B: receptor blocker, lower blood pressure; C: lower cholesterol, quit smoking; D: control blood sugar, reasonable diet; E: aerobic exercise, participate in patient education.