STDs (venereal disease) are traditionally thought of as diseases transmitted through the act of sexual intercourse, with the main lesions occurring in the genital area. They include five types: syphilis, gonorrhea, soft chancre, venereal lymphogranuloma and inguinal granuloma. The main causes are as follows: 1. The disease itself has no specific medicine or is difficult to cure, such as AIDS. 2, the treatment of medication is not regular, or the course of treatment is too short, the treatment is not complete. Many patients do not get formal and effective treatment at the early stage of the disease, they do not go to the hospital, but go to the pharmacy to buy drugs for treatment or go to the street doctor or irregular hospitals for treatment, so as to delay the condition, so that the disease becomes chronic or uncontrollable; 3, STD infected sex partners do not get effective examination or treatment, resulting in re-infection of STDs. Therefore, sexual partners of STD patients should be examined or treated even if they have no symptoms. If there is a high suspicion that he or she is infected with a treatable STD, he or she should be treated with medication first, even if he or she is asymptomatic or until a laboratory report is available. Sexual activity should be prohibited during the period of illness. 4. Untimely or incorrect laboratory reports. Correct and timely laboratory report is an important basis for clinicians to make a correct diagnosis and treatment, such as over the report is not timely or inaccurate, will affect the development of treatment programs or prognosis judgment, especially when a variety of STD co-infections; 5, microbial resistance, the use of antibiotics is ineffective. Some pathogenic microorganisms of STD infection will mutate and drug-resistant strains will appear. Therefore, culture of pathogenic microorganisms and drug sensitivity test should be carried out wherever possible to find out the sensitive antibiotics. 6.When STD patients have multiple microbial infections, drugs targeting multiple specific pathogenic microorganisms are not applied in combination, e.g., drugs targeting only gonococci are not used to kill mycoplasma and chlamydia, and the pathogens cannot be completely eliminated. This situation is prone to occur in the treatment before the laboratory report comes out, or not at all when the laboratory examination. 7, the body resistance is poor, the single use of antibiotics is difficult to completely kill the pathogenic microorganisms, or at present there is no effective drugs to kill, can only be temporarily inhibited, to be the body body resistance is weak and then come out of the activity, such as genital herpes and so on. Or STD lesions are difficult to completely remove at once, the residual lesions are easy to recur, such as condyloma acuminatum. Or repeated large-scale use of broad-spectrum antibiotics lead to the body flora imbalance, in the original STD infection site of the conditional pathogenic bacteria infection, aggravate the clinical symptoms.