Hypertension grade 2 is defined as a systolic blood pressure between 160-179 mmHg and/or a diastolic blood pressure between 100-109 mmHg, which is considered moderate hypertension. Very high risk, also called very high risk, belongs to the risk stratification of hypertensive patients. Clinically, a higher risk stratification indicates that the patient’s hypertension is more severe and the risk of future cardiovascular events is significantly higher. Patients with very high risk of hypertension grade 2 mainly refer to patients with clinical complications of hypertension or combined with diabetes mellitus, and need to be actively given antihypertensive treatment to control blood pressure below 130/80 mmHg. Choose long-acting antihypertensive drugs, combine different mechanisms of antihypertensive drugs for combined antihypertensive treatment, and individualize antihypertensive treatment. In addition to lowering blood pressure, lifestyle modification and control of other cardiovascular risk factors should be actively carried out.