All antiepileptic drugs (AEDs) can produce adverse reactions, the severity of which varies widely among individuals. adverse reactions to AEDs are another major cause of treatment failure. Most adverse reactions are mild, but a few can be life-threatening. The most common adverse reactions include effects on the central nervous system (sedation, sleepiness, dizziness, ataxia, cognition, memory, etc.), effects on multiple systems throughout the body (hematologic, digestive, weight changes, fertility problems, bone health, etc.), and idiosyncratic body reactions. Common adverse reactions can be divided into four categories: dose-related adverse reactions: for example, the sedative effect of phenobarbital, dizziness, diplopia and ataxia caused by carbamazepine and phenytoin sodium are dose-related. Slowly increasing the dose starting from a small dose and not exceeding the maximum therapeutic dose recommended in the instructions as much as possible can alleviate such adverse reactions. Idiosyncratic adverse reactions: Generally appear in the first few weeks of treatment initiation, independent of dose. Some idiosyncratic adverse reactions are rare but potentially life-threatening. Almost all conventional AEDs have been reported with atopic adverse reactions. The main ones are skin damage, severe hepatotoxicity, and hematologic damage. Lamotrigine and oxcarbazepine have also been reported in the newer AEDs. They are generally mild and resolve rapidly after discontinuation of the drug. Some serious adverse reactions require immediate discontinuation and aggressive symptomatic management. Long-term adverse reactions: related to cumulative dose. If the patient is given the smallest dose that can control seizures, gradual withdrawal or dose reduction can be considered after several years of seizure-free treatment to help reduce long-term adverse reactions to AEDs. Teratogenic effects: The incidence of malformations in the offspring of women with G epilepsy is about twice that of normal women. The causes of malformations in offspring are multiple, including genetics, seizures in G, and the use of AEDs. Most researchers believe that AEDs are the main cause of malformations in offspring.