In the early stage of postoperative treatment of children’s brain tumor, we need to give medication such as dehydration, diuretic, hemostasis, prevention of infection, etc. In the later stage, we can decide whether to carry out adjuvant treatment of radiotherapy according to the pathological typing and grade of the brain tumor. The medication for children after brain tumor surgery is somewhat different from that for adults, and the amount of intravenous input should not be too much and the speed of fluid input should not be too fast. In the early stage, we can consider giving mannitol, furosemide, etc. for dehydration and diuretic treatment to avoid further edema and pressure damage of brain tissues after surgery. In the first 3 days after surgery, we can give injectable hemocoagulase to stop bleeding and apply antibiotics such as cefdinir appropriately for preventive or anti-infective treatment. After surgery, routine pathological examination of brain tumor will be performed. If the brain tumor is malignant and of high grade, further treatment should be considered in the later stage, and radiotherapy and other adjuvant treatments will usually be given to control or delay the recurrence of children’s brain tumor after surgery. How to use medication for children’s brain tumors after surgery is very professional, it is recommended to go to neurosurgery department of tertiary hospitals and take appropriate medication under doctor’s guidance.