Long-term hypertension will lead to an increase in pressure in the glomerular capsule of the kidney, causing glomerular fibrosis and subsequent atrophy, as well as sclerosis of the renal arteries. If a patient with hypertension is combined with diabetes and the blood pressure reaches a very high level, such as malignant hypertension, renal failure will occur in a short period of time. Therefore, it is necessary to choose antihypertensive drugs rationally, not only to control blood pressure within the target value, but also to improve their life behavior, such as salt limitation, smoking cessation, alcohol restriction, weight loss for obese patients, strengthening physical exercise, maintaining an optimistic and happy mood, and other risk factors such as high blood lipids and high blood sugar should be treated with intervention.