Drinking alcohol after taking medication is usually not recommended, especially when taking cephalosporins, which should be taken after an interval of 5 days. Although there is no restriction on alcohol consumption for general medications, for patients, alcohol consumption is not beneficial to health and disease recovery, and it is recommended to avoid alcohol consumption after taking medications. As cephalosporin and alcohol will produce disulfiram-like reaction, clinical manifestations of facial flushing, headache, dizziness, abdominal pain, nausea, vomiting, shortness of breath, heart rate acceleration, drowsiness, hallucinations, and other symptoms, the serious case will lead to the death of the patient. Therefore, alcohol should be prohibited within 5 days after taking cephalosporins, and cephalosporins should not be taken within 5 days after drinking alcohol. In addition, drinks containing alcohol should not be consumed. Disulfiram-like reactions may occur in anyone taking cephalosporin antibiotics within 5 days of drinking alcohol. It is safer to recommend taking the medication after the 6th day of drinking. In addition, as the burden on the patient’s heart and kidneys increases during the illness, and the patient is prone to myocarditis or renal dysfunction, the patient should drink plenty of water and rest after taking the medication.