Uremia is a sign that kidney failure has progressed to the end stage and requires hemodialysis or a kidney transplant to stay alive. Without hemodialysis, patients with uremia will soon die due to severe metabolic disorders. Its clinical manifestations are complex and serious, mainly categorized as serious dysfunction of several systems of the human body. 1. heart failure: reduced blood return leads to heart failure, and patients often feel panic, chest tightness, dyspnea, hypertension, shock and other symptoms. 2. endocrine disorders: serious disorders of hormone levels and abnormal body composition, which can be complicated by various endocrine diseases such as hyperuricemia, hypertriglyceridemia, negative nitrogen balance, etc. 3, water-electrolyte imbalance: manifested as dehydration or edema, the balance of sodium, potassium, calcium and phosphorus in the body is broken, metabolic acidosis occurs; 4, electrocardiogram changes: uremia before death can appear the performance of electrocardiogram T-wave hyperacute, because of the production of severe hyperkalemia; 5, uremic face: extreme dryness and itching of the skin, skin pigmentation is serious, manifested as gray; 6, swelling: puffiness of the skin surface Severe, especially serious performance in both lower extremities, can not recover for a long time after pressing; 7, nausea and vomiting: toxic substances in the blood stimulate the gastrointestinal mucosa can cause nausea, vomiting, diarrhea and other gastrointestinal symptoms; 8, dyspnea: dry cough, chest tightness, nocturnal telangiectasia symptoms, blood can not be metabolized causing severe metabolic acidosis, so that the patient’s breathing performance for a long deep breathing; 9, special breath. Exhaled gas with the smell of ammonia, relatively pungent and unpleasant; 10, anemia: blood cell life shortened, the components that make up blood cells such as iron, folic acid, protein serious deficiency, prone to internal bleeding, the presence of bleeding and black stool; 11, the emergence of hallucinations: long-term severe mental abnormalities, such as insomnia, inability to focus, etc., the terminal can develop into hallucinations appear; 12, muscle weakness: muscle weakness as the Peripheral neuropathy with muscle weakness as the main manifestation, also accompanied by abnormal sensation of the limbs, such as hot and cold abnormalities; 13, convulsions: nerve spasms by the action of toxic substances that can not be metabolized, can be manifested as a whole body-wide convulsions; 14, osteoporosis: can occur severe hypocalcemia, hyperparathyroidism, osteoclasts malfunction, the bones become very loose, very easy to fracture; 15, wasting: uremia The terminal manifestation is like the severe wasting in the late stage of cancer, because of the inability to digest and absorb normally, and then easily diarrhea, and the situation of wasting.