Calluses, also known as calluses, is a protective response of the skin to long-term mechanical friction, can be removed in a variety of ways, common methods of physical therapy, drug therapy and medical aesthetic treatment, can be selected according to their own circumstances. 1, physical therapy: for calluses light, no pain, you can use hot water to soften the calluses with tools to scrape or grind them off, but need to be removed several times, can not remove too much at once In order to avoid causing skin damage resulting in infection. At the same time to avoid long-term pressure and friction, it is recommended to wear soft-soled and loose shoes, reduce the number of walks; 2, medication: external application of retinoic acid ointment, as well as oral isotretinoin soft capsules or Avia capsules, can effectively improve the symptoms. Can also be used to remove the keratin exfoliator, such as cleaning the affected area, after the callus parts in the application of keratin exfoliator, stay for ten minutes after part of the callus will fall off on its own. Usually pay attention to disinfection with iodophor to prevent infection; 3, medical treatment: the use of fruit acid or salicylic acid exfoliation, or the use of liquid nitrogen freezing treatment, freezing will be blistered or blood blisters, a month later will gradually dry and fall off. After the trauma is healed, it is recommended to use mucopolysaccharide polysulfate cream to apply the treatment.