The cause of mastocytosis is not well understood. It is mostly thought to be related to endocrine disorders and psychological factors. The decrease in luteinizing hormone secretion and the relative increase in estrogen are important causes of this disease. It is mainly benign hyperplasia of the interstitial mammary glands, which can occur around the ducts and be accompanied by the formation of cysts of various sizes; it can also occur in the ducts and manifest as papillary hyperplasia of the epithelium, accompanied by cystic dilatation of the milk ducts. In addition, there is a type of lobular parenchymal hyperplasia. In recent years, many scholars believe that elevated prolactin is also an important factor in causing mastopathy. In addition, some studies have shown that hormone receptors also play an important role in the pathogenesis of mastoproliferative disease. Qiu Xianhua, Department of General Surgery, Anyang Cancer Hospital So what exactly is the cause of endocrine hormone disorder? It is generally believed that various factors such as neurological, immune and trace elements can cause the imbalance of various endocrine hormones in the body. The external environment, work and living conditions, interpersonal relationships, and neuropsychological factors caused by various stresses can change the internal environment of the human body, thus affecting the function of the endocrine system and causing abnormalities in the secretion of one or several hormones. For example, in a state of chronic stress and anxiety, opioid tension is increased, the neurotransmitter-mediated environment is altered, and estrogen/dopamine disharmony occurs, which leads to increased secretion of PRL, which may cause or aggravate mastopathy.