Hives on the knees should be treated promptly with medications such as antipruritic and antispasmodic drugs. Urticaria topical drugs can choose antipruritic solution, glycerite lotion, etc.; systemic drugs can choose vitamin C, calcium such as calcium sulfate, accompanied by pain, can be given antispasmodic drugs such as brompropyl aminotargetine, etc., can be used antihistamines ranitidine, for cold urticaria, ketotifen, doxepin and other drugs can be used, sun urticaria can be used hydroxychloroquine and so on. When hives on the knee should promptly go to a regular hospital, under the guidance of a professional doctor to choose the appropriate treatment drugs, in order to maximize the quality of life, to prevent the acute development of nausea, vomiting, respiratory distress, suffocation and other serious conditions.