When a patient learns the news of cancer diagnosis, there will be significant psychological changes, and the psychological reactions are divided into four stages: Shock and fear stage: When a patient learns the news of cancer for the first time, the reaction is intense, manifesting as shock and fear, and some physical reactions such as sweating, chills, and increased heart rate will appear. Denial-doubt period: When patients calm down from the intense emotional shock, they often adopt denial attitude to cope with the tension and pain caused by cancer diagnosis. Sima Lei, National Pain Treatment Center of China-Japan Friendship Hospital Anger-depression period: When the patient’s efforts do not change the cancer diagnosis, he/she becomes emotionally irritable, angry, and sometimes aggressive; at the same time, sadness and depression arise. Acceptance-adaptation period: The fact that the disease cannot be changed, the patient will eventually accept and adapt to the fact that he/she has cancer, but most of the patients can hardly return to the state of mind before the disease and often enter into chronic depression and pain. Medical and nursing staff and patients’ family members should actively communicate with patients to help them reduce psychological pressure and make them feel the care of family and society. Patients also need to make self-psychological adjustment and accept the reality of the disease: if we cannot extend the length of life, we can still expand the width of life. Enjoy life more, do what you like to do, what you want to do but have not done, and do not leave regrets in your life.