Rheumatic diseases are a group of diseases that mainly affect joints, bones, muscles, blood vessels and related soft or connective tissues, most of which are autoimmune diseases. Most of them are autoimmune diseases. The onset of disease is insidious and slow, with a long course, and most of them have a genetic predisposition. Diagnosis and treatment are difficult; different autoantibodies can be detected in the blood; good short-term or long-term remission response to non-steroidal anti-inflammatory drugs (NSAID), glucocorticoids and immunosuppressive drugs. Clinical manifestations of rheumatic diseases: 1. There may be fever, rash, oral ulcers, hair loss, and photosensitivity. 2, most of the joint symptoms, about 50% only have pain, heavy red, swelling, heat, pain and impaired function and other comprehensive inflammatory manifestations; mostly multi-joint involvement. The size of the invaded joints varies depending on the type of disease. 3, heterogeneity, that is, the same disease, there are different subtypes, due to the genetic background, different causes of pathogenesis, the mechanism also varies, and therefore the type of clinical manifestations, symptoms, severity and treatment response is not the same. 4, rheumatic diseases are mostly diseases that invade multiple systems, many diseases have overlapping pathologies and similar symptoms, and certain diseases can be a system of a certain performance as the first manifestation. 5.A variety of antibodies and immune complexes (CIC) appear in the serum, and can be deposited in the tissue (skin, synovial membrane) or organs (kidney, liver) to cause disease. 6, Raynaud’s phenomenon is often seen in this type of disease, such as SLE, MCTD.