Fatigue-induced impotence can be treated with proper rest, or with type 5 phosphodiesterase inhibitor therapy (sildenafil, tadalafil, etc.), etc., under the guidance of a doctor. 1. Appropriate rest: for impotence caused by fatigue, patients can rest first, and the symptoms can usually be improved after sufficient rest. 2. Type 5 phosphodiesterase inhibitor treatment: patients with fatigue-induced impotence can be treated with type 5 phosphodiesterase inhibitors under the guidance of a doctor, commonly used drugs such as sildenafil, tadalafil, vardenafil, etc., which can improve the diastolic function of penile cavernous smooth muscle cells and increase cavernous blood perfusion. It is recommended that patients under the guidance of the doctor, strictly comply with the medical advice to use drugs, not blindly use drugs or unauthorized changes in drug dosage, so as not to cause adverse effects on the body, triggering the emergence of other diseases, pay attention to hygiene in life, avoid overwork, enhance physical fitness, improve the body’s immunity.