Urticaria with sulfur powder topical application is not effective, and may also aggravate the condition. Urticaria is a common dermatological disease, is due to the expansion of small blood vessels in the skin and mucous membranes, mainly manifested as angioedema on the skin, red doughnut-shaped bumps, etc., and is accompanied by intense itching symptoms, usually within 24 hours will subside on its own, but it will be repeated episodes. Sulfur powder has its own antiseptic effect, but will cause skin irritation, urticaria patients with sensitive skin, the role of the lesions, may lead to the skin to become more dry and sensitive, itching and rashes will gradually aggravate. Not only no therapeutic effect, but also counterproductive, leading to aggravation of the condition. Urticaria should follow the doctor’s instructions external glycerine lotion, mometasone furoate ointment and other medications, if necessary, oral diclofenac tadalafil, imipramine, fexofenadine and other medications. Urticaria patients are advised to go to the dermatology department of the hospital in a timely manner, strictly comply with the doctor’s prescription medication, can not be used on their own medication.