Stinging urethra and blood when urinating may be caused by urethral injury, such as collision, squeezing, crushing and other trauma, resulting in urethral contusion, laceration, complete or incomplete fracture, which may cause pain, bleeding and difficulty in urination, resulting in stinging urethra and blood when urinating, although this is less common. In addition, it may also be caused by urethral infection, urethral stones, special infections and bladder tumors.1. Urethral infection: due to retrograde infection, bacteria, viruses, fungi or a variety of parasites grow and multiply in the urethral epithelium, causing an inflammatory response in the urethral mucosa, resulting in urethritis and cystitis. Typical manifestations are frequent, urgent, painful urination, discomfort in urination or burning sensation in the urethra, stinging pain and blood in the urethra when urinating; 2. Urethral stones: due to environmental factors, urological diseases and systemic lesions that cause stones in the urinary tract system. When the stones reach the urethra and cannot be discharged normally, they remain blocked in the urethra, and when the patient urinates, the movement of the stones in the urethra may scratch the urethral mucosa and cause stinging pain and blood in the urethra when urinating; 3. The patient will have the performance of urinary frequency, urinary urgency, urinary pain, and when the bladder tuberculosis patient’s condition worsens, there will also be urethral stinging pain and blood in urine; 4, bladder tumor: bladder tumor involves the back and side walls of the bladder, hematuria is a more typical symptom, with the development of the disease, the patient will have symptoms such as bladder irritation signs, difficulty in urination. Patients with urinary tract infection will have their condition controlled after reasonable treatment, and the phenomenon of stinging pain and blood in the urinary tract when urinating will improve. In patients with urinary tract stones, the stones can be removed after treatment, but new stones may be produced and the condition may recur, so it is important to take measures to prevent the recurrence of stones. In addition, for patients with specific infections or tumors, it is recommended to seek prompt medical attention and to be given systematic treatment by a doctor who will integrate the patient’s condition and physical signs.