In terms of tumor treatment purpose, technical methods and efficacy evaluation, various departments sometimes show various differences and contradictions, which makes the multidisciplinary comprehensive tumor treatment “loud thunder but little rain”, and it is very difficult in clinical practice. How to get rid of this dilemma, the authors of this paper put forward new ideas. At present, the treatment of malignant tumors is characterized by the rapid development of various specialties in depth, but the development of horizontal combination among various specialties, especially the development of multidisciplinary integrated treatment, is slow. How to combine different types of therapies has been a difficult problem in clinical practice. The key obstacles are: the lack of consensus clinical decision-making pathways among specialties and the lack of common principles to guide the design of treatment protocols. Technology-centered Disagreement more than consensus The current conventional pathway of tumor treatment is to select treatment methods based on the characteristics of the disease, such as the severity of the disease, centered on the technology and classified according to the indications of that technology. Indeed, each technical approach has its own optimal indications. The single technical approach is applied in a single way, trying to treat tumors at different levels of development with one specialized technique, ignoring the synergistic effect of other related techniques and the role of multidisciplinary integrated treatment, which may easily lead to over-medication, induced treatment or missed treatment. In the face of multiple tumor treatment options available, physicians from different specialties should understand each other’s various treatment techniques and treat them synergistically. For example, the various guidelines or norms published for the treatment of liver cancer mainly provide principles and technical specifications for the selection of first treatment methods, but still lack guidance for the overall design of comprehensive treatment plans. To address this problem, based on the previous principles of liver cancer treatment, the author proposes a new concept of holistic treatment for liver cancer, i.e. MDHT strategy, which emphasizes that the design of tumor treatment plan needs to simultaneously follow six design principles, including systematic, all-round, standardized, individualized, economical (sociological) and dynamic, and is carried out throughout the whole treatment process. Multidisciplinary is the means and holistic view is the goal Modern scientific research has recognized that cancer is both a local lesion and a systemic disease, and theoretically no single treatment can cure cancer from local to systemic. Even early stage liver cancer cannot be completely cured by surgical resection alone, and the so-called radical resection is only a concept in surgical science. mdht strategy, meaning to achieve holistic treatment for patients, and the holistic goal is composed of several local goals. MDHT includes three aspects: 1. To reach a unified understanding in disease diagnosis with the patient as the center. Accurate diagnosis and judgment of all aspects related to the disease are the prerequisites for achieving holistic treatment.2. In the selection of treatment methods, multidisciplinary integration centered on specific diseases, and appropriate treatment plans and methods are selected for the characteristics of each part of the disease.3. In the process of treatment and implementation, mutual coordination centered on technology is used to implement each specific treatment measure. These three aspects form a three-dimensional holistic clinical thinking model. The basic concept of holistic tumor treatment is to adopt different treatment methods and implement a multidisciplinary treatment model for six aspects: local lesions, regional lesions, systemic lesions, organ-based diseases, systemic internal environment and rehabilitation. Now, we will take liver cancer as an example to elaborate. 1. Treatment of local lesions The aim is to rapidly and effectively eliminate or kill tumor cells and reduce tumor load, which is the key step in the comprehensive treatment of liver cancer. In the past, only surgical treatment could meet this requirement, and local ablation treatment for various types of tumors is an extension of surgical treatment. 2. Treatment of regional lesions The aim is to kill or inhibit tumor or residual cancer foci or metastases. Through cell index killing effect to kill cancer cells in a certain proportion, it often cannot completely eliminate cancer cells, especially the tumor stem cells are highly resistant to drugs. Regional therapies such as transcatheter hepatic artery chemoembolization or transcatheter portal vein infusion chemotherapy can be used. 3. Systemic lesion treatment refers to the systemic treatment of extrahepatic lesions. For those who have completed the treatment of local and regional lesions, the focus is on the prevention and control of distant metastasis via blood and lymph, such as the use of immunoactive cell therapy and systemic systemic chemotherapy. The efficacy of systemic chemotherapy has not been satisfactory and is rarely used. For limited extrahepatic metastases, sometimes a combination of appropriate local therapeutic measures is required. 4. Treatment of organ-based disease refers to the treatment of the original disease of the affected organ liver. The background of liver diseases such as chronic hepatitis and cirrhosis is not only the basis of the original disease of liver cancer, but also the basis of multicenter recurrence of liver cancer after the first treatment. Therefore, in order to improve the long-term efficacy, it is necessary to follow the guidelines for the prevention and treatment of chronic hepatitis and liver disease. 5. Treatment of systemic internal environment disorder is the treatment to improve metabolic abnormalities and enhance systemic immunity. Such as simple cytokine therapy to improve the immune status and Chinese medicine therapy to improve the systemic status and eliminate the evil and support the righteousness. 6. Rehabilitation treatment refers to the rehabilitation of diet and life, mind and body environment. Only by doing this step can early stage liver cancer patients be eventually cured or middle and late stage liver cancer patients further improve their quality of life. From local to systemic There is a common philosophy Clinical decision-making ideas include collecting medical history, making clinical diagnosis, formulating treatment plan, implementing treatment and prognosis assessment, which are the prerequisites for developing and implementing MDHT strategies. Multiple treatment approaches are implemented for each treatment goal, including sequential, simultaneous and alternate therapies. The holistic medical view emphasizes that the whole is composed of multiple parts, which is different from the holistic view in traditional medicine where the patient is treated as a whole. Tumors are systemic diseases and the scope of lesions involves multiple local problems, and it is difficult to cure local tumors by treating them alone. The trend is to subdivide the specialties, and each doctor should eventually be positioned to a certain specialty. If we want to have good and efficient multi-disciplinary cooperation, doctors from different disciplines must have the same view in recognizing and fighting tumors, have the same dialectical thinking, and have a relatively unified treatment model; consider designing treatment plans from local to systemic at the same time, i.e. to treat various local problems, and finally achieve holistic treatment.