According to the route of administration, skin whitening preparations are divided into oral, intravenous and topical topical applications. Oral medications for skin whitening are convenient and popular among patients. Oral anamnestic acid is a popular oral whitening drug in Japan. However, its long-term safety has yet to be studied. Recently, there has been a great interest in glutathione, which plays an important role in melanin metabolism. Oral administration is generally advocated in high doses because it is broken down by the intestinal tract. Glutathione is an antioxidant and plays an important role in the skin by neutralizing oxygen free radicals in the skin. They have also done a series of experiments. It was finally confirmed that the drug is effective, but the effect in the effect on the newborn melanin is obvious. And it has less effect on the original pigment. Therefore, in the treatment of melasma etc., we choose comprehensive treatment, and the use of laser treatment for the spots combined with the use of the above drug can solve the whitening needs of patients to a greater extent!