Patient Wang Moumou, female, 21 years old, was admitted to the hospital with “recurrent paroxysmal abdominal pain for 2 months, and CT examination showed pancreatic occupancy”. After completing various examinations upon admission, she was diagnosed with cystic solid occupancy of the tail of the pancreas. Because the patient was a young female, unmarried and previously healthy, and the borders of her tumor in the tail of the pancreas were clear in the preoperative analysis, and in order to reduce the patient’s postoperative pain and shorten the perioperative period, we decided to perform a minimally invasive surgery for the patient: laparoscopic resection of the tail of the pancreas with preservation of the spleen. The operation was successfully completed in 2.5 hours, creating a precedent for this type of surgery in Jinan. Since the pancreatic tumor is adjacent to important organs and blood vessels, the operation is technically demanding and difficult, and the surgeon must have skillful laparoscopic surgery skills and superior microscopic dissection techniques, and it is known that only a few hepatobiliary and pancreatic specialists in the province can perform such a difficult operation independently. Firstly, the intra-abdominal operation is performed through four poked holes in the abdominal wall, which greatly reduces the trauma, bleeding and postoperative pain of the patient and speeds up the postoperative recovery. Secondly, the use of good laparoscopic vision and skilled laparoscopic surgical skills reduce the occurrence of intraoperative and postoperative complications such as pancreatic leakage and bleeding, and ensure patient safety. Third, the patient’s spleen was preserved, which maximized the protection of the patient’s normal body functions. The patient was discharged from the hospital 6 days after surgery.