Bronchitis patients choose azithromycin or cefixime treatment, and the patient’s sensitivity to drugs, the type of infection bacteria, etc., due to mycoplasma, chlamydia infection caused by bronchitis choose azithromycin effect is better, by the bacterial infection caused by bronchitis two kinds of drugs can be chosen, the efficacy of the drug and the patient’s sensitivity to the drug has a direct relationship. Azithromycin belongs to macrolide antibiotics, and has good efficacy in bronchitis caused by Mycoplasma, Chlamydia, Streptococcus pneumoniae, Haemophilus influenzae, Legionella and other flora. Azithromycin is contraindicated in patients with allergy, cholestatic jaundice and hepatic insufficiency. Adverse reactions such as abdominal pain, diarrhea, dizziness, headache and rash may occur with Azithromycin. Cefixime belongs to the third generation of cephalosporins, which can inhibit the synthesis of bacterial cell wall and thus achieve bactericidal effect. It is effective in bronchitis caused by sensitive flora such as Streptococcus spp, Haemophilus influenzae, Staphylococcus spp and Pseudomonas aeruginosa. Common adverse reactions to Cefixime are rash, urticaria, headache, nausea and vomiting. Cefixime is contraindicated in allergic populations. Therefore, patients with bronchitis should go to the hospital in time and choose the appropriate medication under the guidance of the doctor. It should be noted that patients with mild bronchitis generally do not need to use antibiotic treatment, usually according to the patient’s symptoms, symptomatic supportive treatment can be. Drugs need to be used under the guidance of a physician.