The titer indicates the concentration of the virus in the viral suspension and is a common method of clinical examination and laboratory testing. A titer of 1:16 often indicates a syphilis patient with a relatively high titer value, and the treatment time is about 1-2 years, but the specific needs to be determined according to the patient’s condition. Syphilis is an infectious disease disease caused by syphilis spirochete infection, according to the course of the disease can be divided into a syphilis, two syphilis, three syphilis. The normal syphilis titer is 1:2, titer 1:16 considered for syphilis phase II, belongs to the early stage of infection, there is a strong infectious, should be actively treated. The treatment of syphilis phase II usually selects benzathine penicillin for intramuscular injection treatment, or intravenous infusion of ceftriaxone, as well as oral doxycycline, tetracycline hydrochloride, etc., but the specific medication and treatment time need to be developed by the doctor. Usually after 6 months of early adequate and standardized treatment, the titer will drop to below 1:4, and the test result can turn negative after about 1-2 years of standardized treatment. However, it is still necessary to review regularly for 2-3 years after treatment, once every 3 months in the first year and once every 6 months in the second year, in order to observe changes in titers. If the titer ratio decreases and does not recur, it means that syphilis treatment is more effective. Patients with syphilis can develop lesions in bones and joints, nerves, eyes and other multiple sites if left untreated for a long time, so they should be treated and monitored regularly to avoid serious damage. In addition, the sexual partners of syphilis patients should be examined and treated at the same time, and sexual intercourse is prohibited during the treatment period. Daily attention should be paid to maintaining a positive state of mind, strengthening personal hygiene, enhancing physical fitness with proper exercise, and developing a healthy and regular diet and living habits.