Thrombosis is a major cause of catheter failure. Intracatheter and intravascular thrombosis can occur after catheter placement, as well as fibrin attachment to the inner wall of the catheter or wrapping around the outer wall to form an inner and outer sheath (fibrous cuff-like changes), resulting in partial or complete catheter occlusion. Infection is a common complication of catheters. It can be classified as exit infection, tunnel infection, infection within the catheter lumen, and severe sepsis. The pathogens are mainly Gram-positive bacteria such as Staphylococcus aureus (mainly from the upper respiratory mucosa of health care and other personnel) and Staphylococcus epidermidis (mainly from the surface of the article), as well as Gram-negative bacilli and enterococci. They should be treated empirically with simultaneous cultures and antibiotics selected according to drug sensitivity. In the case of intracatheter infections, systemic medication cannot reach the bacterial site and the bacteria will spread through the bloodstream during dialysis. Antibiotics can be chosen to be dripped from the catheter lumen. Antibiotics are usually administered for two weeks, and if they do not work, the catheter should be removed decisively. The tube is usually re-tubed in another location, but there is still a possibility of reinfection in the original location. In order to prevent complications, the treatment and care after placement is very important. Early after placement, attention should be paid to complications such as blood leakage and exudate, and hygiene and dryness should be maintained. The use should be strictly aseptic and minimize unnecessary additional operations. After use, the tube should be sealed with appropriate concentration of heparin according to the intubation site and the patient’s coagulation, and local fixation and dressing should be done. And do the relevant education to the patients. Reduce activity after femoral vein placement. The catheter is generally not used for other purposes. If necessary, the catheter must be sealed after use.