1. There may be specific reactions to standard doses of anesthetics. Caution is needed when applying anesthetics when patients need to perform surgery; 2. There is a possibility of overreaction to standard doses of certain drugs, such as anti-diuretic drugs that can lead to water intoxication; 3. The high pain threshold may mask infection or physical injury, and some patients do not call for pain until the infection is very severe, and it is difficult to point out specifically where the pain is; Zhang Huiwen, Department of Pediatric Endocrinology, Shanghai Xinhua Hospital 4. No matter what age Obvious snoring needs to be evaluated for obstructive sleep apnea; 5. Lack of vomiting reflex, emetic drugs may be ineffective and repeated application can lead to poisoning; if there is no vomiting reflex after eating spoiled food, the organism will absorb toxic substances; if vomiting occurs in a patient with Prader-Willi syndrome, it may mean a life-threatening condition; 6. Be alert to serious gastric diseases such as Acute idiopathic gastric dilatation, gastric ischemic necrosis, gastric perforation, which may be related to a large amount of food intake at one time; 7. Pay attention to the central adrenal insufficiency that may occur under stress; 8. Patients with the following problems need to do sleep monitoring as early as possible, such as severe obesity, chronic respiratory tract infection, asthma, sleep apnea at night, easy to wake up at night, and more sleep during the day; 9. Due to the sticky saliva in the mouth Need to pay attention to oral cleaning to prevent dental caries and tooth loss.