Shortness of breath in the chest is a symptom, and the most fundamental cause is lack of oxygen. Chest tightness and shortness of breath are related to several organs: 1, heart: if the patient has coronary heart disease, hypertensive heart disease, infective endocarditis, etc., causing the heart itself ejection fraction as well as contraction capacity, it will lead to a decrease in ejection fraction as well as circulatory disorders, which will cause chest tightness and shortness of breath; 2, respiratory system: it will combine the following kinds of diseases, including bronchitis, chronic bronchitis, asthma, etc., which will also cause Chest tightness and shortness of breath; 3, anemia as well as hyperthyroidism: ischemia and hypoxia will also cause chest tightness and shortness of breath if they have seriously affected the body’s needs; 4, psychological diseases: these patients are often neglected, even without cardiac, respiratory, and metabolic diseases, the symptoms of chest tightness and shortness of breath will still occur in the case of psychological intervention. Each disease requires different treatment, therefore, when a patient presents with shortness of breath in the chest, medical history inquiries, multi-system screening, and profound patient communication should be done in order to clearly identify what exactly is causing the patient’s shortness of breath in the chest.