Premature heartbeats are a common clinical condition and most patients without underlying heart disease or occasional premature beats do not require medication. Most patients with no underlying heart disease or occasional premature beats do not need medication, but those with severe beats need to take medication as prescribed by their doctors and should not use medication on their own. There is no such thing as the best medicine for premature beats, but the best medicine is the one that suits you. If you find premature beats, you should not use medication on your own, but should seek medical advice in a timely manner. Premature beats can be classified as sinus, atrial, atrioventricular junction and ventricular according to the origin of the abnormal beats, among which ventricular and atrial premature beats are more common. Not all patients with premature heartbeats need to be treated with medication, and the choice of medication should be based on the patient’s individual condition and under the guidance of a physician. Patients with episodic atrial premature contractions with less than 5 episodes per minute do not need medication, but should improve their lifestyle, avoid excessive stress or strain, reduce alcohol, strong tea and coffee, and have regular check-ups. Patients with atrial premature beats with more than or equal to 6 episodes per minute can take propafenone or amiodarone under the guidance of a physician to control the frequency of premature beats, and should pay attention to checking liver and kidney function and thyroid function during the medication period. Patients with underlying heart disease need to adjust their medication regimen according to the primary disease. Catheter radiofrequency ablation may be considered for patients who are not effective with medication or who are intolerant to medication. For episodic ventricular premature contractions with no risk of fatal origin, drug therapy is also not required, and improvement of lifestyle is sufficient. If the effect of medication alone is not good, radiofrequency ablation can be considered. Patients who have induced other ventricular arrhythmias at the site of origin need to undergo radiofrequency ablation or implantation of a pacemaker with defibrillation as their condition may be life-threatening. The use of medications for premature beats is determined by the type and risk of premature beats. Commonly used medications include metoprolol succinate to lower the heart rate and propafenone and amiodarone to control premature contractions. Patients with underlying heart disease must be treated with medications that are adjusted based on the original disease. The specific use of medications must be directed by a physician, and liver and kidney function, thyroid function and heart rate changes must be monitored during the course of medication. There is no one-size-fits-all medication for premature beats, and the best treatment is to choose the right treatment and treatment plan for you with the help of your physician.