A variety of etiologies can cause headache and brow bone pain, some with nausea and vomiting, the most common in ophthalmology is glaucoma. The most prominent symptom in acute closed-angle glaucoma grand mal is blurred vision with headache, nausea, and vomiting. The diagnosis can be clearly made when corneal edema, shallowing of the anterior chamber, dilated pupils and elevated IOP measurements can be seen under the slit lamp and IOP meter in ophthalmology. Glaucoma and cranio-cerebral diseases should be differentiated, like cerebral hemorrhage or acute cerebral infarction, which can also present with headache and nausea, accompanied by blurred eye vision. In this case, the patient should go to neurology first, and then go to ophthalmology for consultation after neurology excludes cranio-cerebral diseases, and then can determine glaucoma.