Some acute urticaria caused by infections and clear allergens usually do not recur after controlling the primary disease and avoiding allergens. Chronic urticaria, whose cause cannot be clearly identified, can be controlled by medication, but it is difficult to be completely cured. The causes of urticaria are complex, and most of them cannot be clearly identified, thus making treatment difficult. Some acute urticaria and infectious urticaria with clear allergens can be cured by actively fighting infection and avoiding allergens. For urticaria of unknown etiology, antihistamines can be used under the guidance of a doctor, such as loratadine, cetirizine, fexofenadine, etc., which can play an anti-allergic role in relieving itching symptoms and promoting rash subsidence. If the situation is more serious, hydroxychloroquine, tretinoin and other drugs can also be used orally. For refractory chronic spontaneous urticaria that is ineffective with the above conventional treatments, biologics (e.g. omalizumab) and immunosuppressants (cyclosporine, etc.) can be used. Specifically, you need to visit the hospital and follow the doctor’s instructions for medication.