The severity of drug rash is different, the degree of difficulty in curing is also different, the condition of milder patients can gradually improve after stopping the use of allergenic drugs, but the condition of the more serious patients, there can be multi-organ damage, or even life-threatening, need to be timely in the guidance of the doctor to carry out the treatment. The first step in the treatment of drug rash is to stop the use of sensitizing drugs, drink more water or intravenous fluids to accelerate the discharge of drugs. Mild drug rash can use antihistamines, vitamin C and calcium, etc., localized if the erythema, papules, can be used externally glycerine lotion or glucocorticoid drugs. Severe drug rash need to use glucocorticosteroids such as dexamethasone and methylprednisolone early and in sufficient quantity. The development of drug rash patients can appear hypoproteinemia, water and electrolyte disorders, etc., serious cases can endanger the patient’s life, resulting in greater difficulty in treatment! The appearance of drug rash need to consult a doctor in time, follow the doctor’s prescription medication, to avoid aggravation of the condition.