For years I have been asked if I am prone to bowel cancer after gallbladder removal. This is also a question that we surgeons would like to clarify. If it is true that the gallbladder is prone to intestinal cancer after gallbladder removal, then of course the gallbladder must be removed with caution. In this regard, I will provide three aspects of scientific basis. 1. First, there is no direct evidence that gallbladder resection causes bowel cancer. It has been reported that about 10% of colorectal cancer patients have a history of gallbladder removal; while only about 5% of non-colorectal cancer patients have a history of gallbladder removal. It seems that people with gallbladder removal have a higher chance of getting colorectal cancer. However, this is only a correlation, not a causal relationship. To date, there is no direct evidence that gallbladder removal induces colorectal cancer. Therefore, people who have had gallbladder removal should not be alarmed that they may get colorectal cancer. 2.So what exactly is the relationship between bowel cancer and gallbladder removal? Recently, British scientists studied more than 450,000 patients with gallbladder disease who had or had not had gallbladder removal, and found that there is no direct causal relationship between bowel cancer and gallbladder removal. This relationship stems from the fact that gallbladder stones were initially associated with bowel cancer and gallbladder removal was performed before bowel cancer was diagnosed. Therefore, since gallbladder stones are relatively easy to diagnose, it is important to be aware of any other coexisting discomfort in the right upper abdomen before surgery. The Appendix is a good English reference. 3. Metabolic syndrome and irregular lifestyle are both common risk factors for the development of bowel cancer and gallstones. The two share part of the same mechanism in metabolic abnormalities. Therefore, patients with gallstones should adjust their living habits, eat lightly and lead a bland life. Of course, both bowel cancer and gallstones are multifactorial diseases, and adjusting lifestyle habits may not necessarily avoid getting bowel cancer and gallstones completely. In any case, we can reduce the occurrence of metabolic syndrome and also reduce the incidence of bowel cancer and gallstones by adjusting our living habits.