The types and causes of heat stroke are different, but the basic treatment measures are the same. I. Cooling treatment: Rapid cooling is the basis of treatment, and rapid cooling determines the patient’s prognosis. 1. Extracorporeal cooling: transfer the patient to a well-ventilated low-temperature environment, remove clothing, and simultaneously perform skin-muscle massage to promote heat dissipation. For patients without deficiency, cold water immersion bath or ice water immersion bath, immerse the patient’s body (except the head) in as much cold water as possible from 2.0 to 14.0℃ and keep stirring the water to keep cold water on the skin surface, and place ice cubes wrapped with wet towels around the top of the head. This method can lower the body temperature from 43.3°C to below 40.0°C within 20 minutes. Evaporative cooling is used to cool the deficient person, such as repeatedly wiping the skin with cold water at 15°C, using an electric fan or air conditioner. Stop cooling when the body temperature drops to 39°C. 2. In vivo cooling: If in vitro cooling is ineffective, use iced saline for gastric or rectal irrigation, or sterile physiological saline for peritoneal cavity irrigation or hemodialysis. 3. Drug cooling to control chills. Second, treatment of complications: 1. Comatose patients should be endotracheally intubated and airway protected to prevent misaspiration. Intravenous infusion of mannitol in case of increased intracranial pressure. In epileptic seizures, intravenous infusion of diazepam. 2. Fluid resuscitation: Patients with hypotension should have intravenous infusion of saline or lactated Ringer’s solution to restore blood volume. Do not use vasoconstrictors to avoid affecting skin heat dissipation. 3. Multi-organ failure: symptomatic supportive treatment should be given.