Sperm abnormalities in men do not cause fetal heart disease, but chromosomal abnormalities in men may lead to fetal congenital heart disease, the causes of this disease mainly include maternal factors, genetic factors and physical and chemical factors. 1. Maternal factors: During pregnancy, many factors may lead to fetal congenital heart disease, such as toxoplasmosis, rubella virus, cytomegalovirus, herpes simplex virus, etc.; or antibiotics such as macrolides, amides and other drugs. 2. Genetic factors: Fetal heart disease is associated with a single gene mutation, or due to multiple pairs of alleles controlling genetic traits, and related to the environment or family history, so if the father or mother carries the gene for congenital heart disease, it may lead to fetal heart disease. 3. Physical and chemical factors: pregnant women smoking during pregnancy or second-hand smoke will increase the incidence of fetal heart disease; if pregnant women exposed to pesticides, insecticides and other environments during pregnancy, or consumption of aspirin, birth control pills, analgesics, estrogen, etc. in early pregnancy may increase the risk of congenital heart disease.